Friday’s NFL odds matchup between San Diego and San Francisco is the final game of the preseason before the regular season begins next Thursday between Tennessee and Pittsburgh, and these two Californian teams may take it easy. However, it’s the visitors who have more to play for.

49ers vs Chargers odds – Friday, September 4, 10:15 PM ET

The 49ers came away with a 20-13 win in Dallas, scoring 10 points in the last four minutes of the contest. Rookie Glen Coffee continued his impressive camp by averaging 4.3 yards on eight carries, while fellow first-year back Kory Sheets added a pair of scores for the 49ers. San Francisco must be excited about the depth they have in the backfield, as that could allow them to keep Frank Gore fresh throughout the season. Nate Davis, another rookie, went 10-of-15 for 132 yards, and he could be pushing Alex Smith for the No.2 spot behind starter Shaun Hill. Smith knows the offense better than Davis, but he’s also been there since 2005 and still hasn’t locked down the starter’s role.

The Chargers lost 27-24 on a late touchdown pass, but they had some positives to come out of the game. Shawne Merriman moved around alright after missing all of last year with knee surgery, which dropped the Chargers in most sportsbook software across the country. Philip Rivers went 10-of-15 for 185 yards and a touchdown, while receiver Vincent Jackson broke out for a pair of big plays. You can’t read too much into giving up the game that late, as most of the defense were second-string players, at best.

Your offshore sportsbook is favoring the Chargers by 3.5 points, and at most, their second-string defense will want to redeem themselves after giving away the Atlanta game. But you should pay attention to the 49ers, who many are calling a sleeper pick this year, in the same vein that Arizona was, although that may be pushing it a little. Davis, Coffee and Sheets could be playing for the future, but a solid performance could at least get them in the lineup, where they could learn some valuable experience. Go with the 49ers in your NFL picks on Friday.